Uncertainty is the root of all scientific inquiry and discovery.  The pursuit of the unknown, with all of the risks and rewards that entails, is the daily work of science and scientists. In our effort to glean constructive and innovative approaches to uncertainty, there are no better fields to look to than those which sit at the bleeding edge of scientific discovery—astrophysics and particle physics. Astrophysics does this from the surface of the Earth into the deepest depths of the universe and while high energy particle physics probes the ultra-hot and dense earliest moments of the universe. This panel provides a glimpse into the worlds of astrophysics and particle physics— the challenges, the uncertainty, the failures and successes, then delves deeply into the most uncertain aspects of this research with a review of exciting new discoveries and frontiers, from merging black holes and neutron stars, to exoplanets, to supernovae and the first seconds of the infant universe.